Green, E. K., Norton, N., Peirce, T., Grozeva, Detelina  ORCID: https://orcid.org/0000-0003-3239-8415, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610
2006.
Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation.
Molecular Psychiatry
11
(9)
, pp. 798-799.
10.1038/sj.mp.4001853
|
Abstract
Recently, Sachs et al.1 reported intra-familial association of a frame-shift mutation at the extreme 3' end of exon 12 of the gene Disrupted in Schizophrenia 1 (DISC1) with schizophrenia and schizoaffective phenotypes. In our own sample, we identified this mutation in none of 655 schizophrenia cases but two of 694 non-psychiatrically screened controls. Our findings suggest that this mutation may not play a major role in influencing susceptibility to psychosis.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Nature Publishing Group |
| ISSN: | 1359-4184 |
| Last Modified: | 27 Oct 2022 08:23 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/62135 |
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